Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery

• Главные авторы: Glaucio Valdameri (Автор), Diogo Henrique Kita (Автор), Julia de Paula Dutra (Автор), Diego Lima Gomes (Автор), Arun Kumar Tonduru (Автор), Thales Kronenberger (Автор), Bruno Gavinho (Автор), Izadora Volpato Rossi (Автор), Mariana Mazetto de Carvalho (Автор), Basile Pérès (Автор), Ingrid Fatima Zattoni (Автор), Fabiane Gomes de Moraes Rego (Автор), Geraldo Picheth (Автор), Rilton Alves de Freitas (Автор), Antti Poso (Автор), Suresh V. Ambudkar (Автор), Marcel I. Ramirez (Автор), Ahcène Boumendjel (Автор), Vivian Rotuno Moure (Автор)
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• Опубликовано: MDPI AG, 2023-04-01T00:00:00Z.
• Предметы: article
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Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone <b>4a</b> (<b>C4a</b>). Molecular docking and in vitro assays using ABCG2 and P-glycoprotein...