Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors

• Main Authors: Fernando Durães (Author), Andreia Palmeira (Author), Bárbara Cruz (Author), Joana Freitas-Silva (Author), Nikoletta Szemerédi (Author), Luís Gales (Author), Paulo Martins da Costa (Author), Fernando Remião (Author), Renata Silva (Author), Madalena Pinto (Author), Gabriella Spengler (Author), Emília Sousa (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The overexpression of efflux pumps is one of the causes of multidrug resistance, which leads to the inefficacy of drugs. This plays a pivotal role in antimicrobial resistance, and the most notable pumps are the AcrAB-TolC system (AcrB belongs to the resistance-nodulation-division family) and the Nor...