Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

• Main Authors: Silvia Gleitze (Author), Omar A. Ramírez (Author), Ignacio Vega-Vásquez (Author), Jing Yan (Author), Pedro Lobos (Author), Hilmar Bading (Author), Marco T. Núñez (Author), Andrea Paula-Lima (Author), Cecilia Hidalgo (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione peroxidase 4 (GPX4), a key intracellular antioxidant re...