Zolmitriptan Intranasal Spanlastics for Enhanced Migraine Treatment; Formulation Parameters Optimized via Quality by Design Approach

• Glavni autori: Asmaa Saleh (Autor), Maha Khalifa (Autor), Seham Shawky (Autor), Amjaad Bani-Ali (Autor), Heba Eassa (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Zolmitriptan is a potent second-generation triptan prescribed for migraine attacks. It suffers low bioavailability (40%) after oral administration due to the hepatic first-pass metabolism. Spanlastics are surfactant-based elastic vesicular drug carrier systems. This study aimed to design and optimiz...