A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain

• Main Authors: Takayuki Sakai (Author), Aya Ogata (Author), Hiroshi Ikenuma (Author), Takashi Yamada (Author), Saori Hattori (Author), Junichiro Abe (Author), Shinichi Imamura (Author), Masanori Ichise (Author), Mari Tada (Author), Akiyoshi Kakita (Author), Hiroko Koyama (Author), Masaaki Suzuki (Author), Takashi Kato (Author), Kengo Ito (Author), Yasuyuki Kimura (Author)
• Format: Book
• Published: SpringerOpen, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neuropathological conditions such as Alzheimer's...