A single immunization with MVA expressing GnGc glycoproteins promotes epitope-specific CD8+-T cell activation and protects immune-competent mice against a lethal RVFV infection.

• Автори: Elena López-Gil (Автор), Gema Lorenzo (Автор), Esther Hevia (Автор), Belén Borrego (Автор), Martin Eiden (Автор), Martin Groschup (Автор), Sarah C Gilbert (Автор), Alejandro Brun (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

BACKGROUND: Rift Valley fever virus (RVFV) is a mosquito-borne pathogen causing an important disease in ruminants often transmitted to humans after epizootic outbreaks in African and Arabian countries. To help combat the spread of the disease, prophylactic measures need to be developed and/or improv...