Intermittent preventive treatment with sulphadoxine-pyrimethamine but not dihydroartemisinin-piperaquine modulates the relationship between inflammatory markers and adverse pregnancy outcomes in Malawi.

• Main Authors: Kaylene Cheng (Author), Elizabeth H Aitken (Author), Wina Hasang (Author), Niamh Meagher (Author), David J Price (Author), Mwayiwawo Madanitsa (Author), Victor Mwapasa (Author), Kamija S Phiri (Author), James Dodd (Author), Feiko O Ter Kuile (Author), Stephen J Rogerson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Women in malaria-endemic areas receive sulphadoxine-pyrimethamine (SP) as Intermittent Preventive Treatment in Pregnancy (IPTp) to reduce malaria. While dihydroartemisinin-piperaquine (DP) has superior antimalarial properties as IPTp, SP is associated with superior fetal growth. As maternal inflamma...