Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis

• Main Authors: Gemma Pujadas (Author), Laurie L. Baggio (Author), Kiran Deep Kaur (Author), Brent A. McLean (Author), Xiemin Cao (Author), Daniel J. Drucker (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates beta cell function and improves glycemia through its incretin actions. GIP also regulates endothelial function and suppresses adipose tissue inflammation through control of macrophage activity. Activation of the...