Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches

The lipid nanoparticle (LNP) has been so far proven as a strongly effective delivery system for mRNA and siRNA. However, the mechanisms of LNP's distribution, metabolism, and elimination are complicated, while the transportation and pharmacokinetics (PK) of LNP are just sparsely investigated an...

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Main Authors: Wei Wang (Author), Shiwei Deng (Author), Jinzhong Lin (Author), Defang Ouyang (Author)
Format: Book
Published: Elsevier, 2024-10-01T00:00:00Z.
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3rd Floor Main Library

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