An attenuated Shigella mutant lacking the RNA-binding protein Hfq provides cross-protection against Shigella strains of broad serotype.

• Main Authors: Jiro Mitobe (Author), Ritam Sinha (Author), Soma Mitra (Author), Dhrubajyoti Nag (Author), Noriko Saito (Author), Ken Shimuta (Author), Nobuo Koizumi (Author), Hemanta Koley (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Few live attenuated vaccines protect against multiple serotypes of bacterial pathogen because host serotype-specific immune responses are limited to the serotype present in the vaccine strain. Here, immunization with a mutant of Shigella flexneri 2a protected guinea pigs against subsequent infection...