Neuroprotective Effect of Tricyclic Pyridine Alkaloids from <i>Fusarium lateritium</i> SSF2, against Glutamate-Induced Oxidative Stress and Apoptosis in the HT22 Hippocampal Neuronal Cell Line

• Main Authors: Dahae Lee (Author), Hyun Gyu Choi (Author), Ji Hye Hwang (Author), Sang Hee Shim (Author), Ki Sung Kang (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive glutamate damages neuronal cells via the accumulation of intracellular reactive oxygen species (ROS), calcium ion (Ca²⁺) influx, depolarization of mitochondrial membrane potential, and apoptosis, which may result in the development of chronic neurodegenerative diseas...