A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease

• Main Authors: Emily Clarke (Author), Pawel Stocki (Author), Elizabeth H. Sinclair (Author), Aziz Gauhar (Author), Edward J. R. Fletcher (Author), Alicja Krawczun-Rygmaczewska (Author), Susan Duty (Author), Frank S. Walsh (Author), Patrick Doherty (Author), Julia Lynn Rutkowski (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Single domain shark antibodies that bind to the transferrin receptor 1 (TfR1) on brain endothelial cells have been used to shuttle antibodies and other cargos across the blood brain barrier (BBB) to the brain. For these studies the TXB4 brain shuttle was fused to a TrkB neurotrophin receptor agonist...