Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups

• Main Authors: Maria Łastowska (Author), Ewa Matyja (Author), Anna Sobocińska (Author), Bartosz Wojtaś (Author), Magdalena Niemira (Author), Anna Szałkowska (Author), Adam Krętowski (Author), Agnieszka Karkucińska‐Więckowska (Author), Magdalena Kaleta (Author), Maria Ejmont (Author), Magdalena Tarasińska (Author), Marta Perek‐Polnik (Author), Bożenna Dembowska‐Bagińska (Author), Maciej Pronicki (Author), Wiesława Grajkowska (Author), Joanna Trubicka (Author)
• Format: Book
• Published: Wiley, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The majority of supratentorial ependymomas in children contain oncogenic fusions, such as ZFTA-RELA or YAP1‐MAMLD1. In contrast, posterior fossa (PF) ependymomas lack recurrent somatic mutations and are classified based on gene expression or methylation profiling into group A (PFA) and grou...