NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

• Main Authors: Sachi Matsuda (Author), Hiroyuki Nishikawa (Author), Anna Fukatsu (Author), Yuko Kurokawa (Author), Maho Tsubota (Author), Fumiko Sekiguchi (Author), Shogo Tokuyama (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dy...