NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

• Κύριοι συγγραφείς: Sachi Matsuda (Συγγραφέας), Hiroyuki Nishikawa (Συγγραφέας), Anna Fukatsu (Συγγραφέας), Yuko Kurokawa (Συγγραφέας), Maho Tsubota (Συγγραφέας), Fumiko Sekiguchi (Συγγραφέας), Shogo Tokuyama (Συγγραφέας), Atsufumi Kawabata (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dy...