Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway

• Main Authors: Ting Gui (Author), Qingfa Chen (Author), Jiangsong Li (Author), Ke Lu (Author), Chen Li (Author), Bin Xu (Author), Yang Chen (Author), Jingwen Men (Author), Gerd A. Kullak-Ublick (Author), Weihua Wang (Author), Zhibo Gai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in mitochondrial damage and oxidative stress, which can cause further progression of CKD.Methods: This study assessed the therapeutic effect...