Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway

• Príomhchruthaitheoirí: Ting Gui (Údar), Qingfa Chen (Údar), Jiangsong Li (Údar), Ke Lu (Údar), Chen Li (Údar), Bin Xu (Údar), Yang Chen (Údar), Jingwen Men (Údar), Gerd A. Kullak-Ublick (Údar), Weihua Wang (Údar), Zhibo Gai (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in mitochondrial damage and oxidative stress, which can cause further progression of CKD.Methods: This study assessed the therapeutic effect...