Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide

• Main Authors: Verena Pichler (Author), Marius Ozenil (Author), Karsten Bamminger (Author), Chrysoula Vraka (Author), Marcus Hacker (Author), Oliver Langer (Author), Wolfgang Wadsak (Author)
• Formato: Livro
• Publicado em: SpringerOpen, 2019-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other 11C-labelled radiotracers, therefore...