Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision

• Main Authors: Hubert Denise (Author), Sterghios A. Moschos (Author), Benjamin Sidders (Author), Frances Burden (Author), Hannah Perkins (Author), Nikki Carter (Author), Tim Stroud (Author), Michael Kennedy (Author), Sally-Ann Fancy (Author), Cris Lapthorn (Author), Helen Lavender (Author), Ross Kinloch (Author), David Suhy (Author), Romu Corbau (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TT-034 (PF-05095808) is a recombinant adeno-associated virus serotype 8 (AAV8) agent expressing three short hairpin RNA (shRNA) pro-drugs that target the hepatitis C virus (HCV) RNA genome. The cytosolic enzyme Dicer cleaves each shRNA into multiple, potentially active small interfering RNA (siRNA)...