Identification of a Small Molecule That Inhibits the Interaction of LPS Transporters LptA and LptC

• Main Authors: Xiaowei Dai (Author), Min Yuan (Author), Yu Lu (Author), Xiaohong Zhu (Author), Chao Liu (Author), Yifan Zheng (Author), Shuyi Si (Author), Lijie Yuan (Author), Jing Zhang (Author), Yan Li (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The need for novel antibiotics has become imperative with the increasing prevalence of antibiotic resistance in Gram-negative bacteria in clinics. Acting as a permeability barrier, lipopolysaccharide (LPS) protects Gram-negative bacteria against drugs. LPS is synthesized in cells and transported to...