Identification of a Small Molecule That Inhibits the Interaction of LPS Transporters LptA and LptC

• मुख्य लेखकों: Xiaowei Dai (लेखक), Min Yuan (लेखक), Yu Lu (लेखक), Xiaohong Zhu (लेखक), Chao Liu (लेखक), Yifan Zheng (लेखक), Shuyi Si (लेखक), Lijie Yuan (लेखक), Jing Zhang (लेखक), Yan Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The need for novel antibiotics has become imperative with the increasing prevalence of antibiotic resistance in Gram-negative bacteria in clinics. Acting as a permeability barrier, lipopolysaccharide (LPS) protects Gram-negative bacteria against drugs. LPS is synthesized in cells and transported to...