Segmental Upregulation of ASIC1 Channels in the Formalin Acute Pain Mouse Model

• Main Authors: María Natalia Gobetto (Author), Libia Catalina Salinas Castellanos (Author), Natalia Estefanía Contreras (Author), Alejandro Omar Sodero (Author), Damián Alejandro Cambiagno (Author), Georgina Oriana Mingolo Malnati (Author), Mayra Micaela Montes (Author), Osvaldo Daniel Uchitel (Author), Carina Weissmann (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Hindpaw injection of formalin in rodents is used to assess acute persistent pain. The response to formalin is biphasic. The initial response (first minutes) is thought to be linked to inflammatory, peripheral mechanisms, while the latter (around 30 min after the injection), is linked to...