Hybrid Quinolinyl Phosphonates as Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation against Topoisomerase 1B (TOP1B)

• Main Authors: Asier Selas (Author), María Fuertes (Author), Estela Melcón-Fernández (Author), Yolanda Pérez-Pertejo (Author), Rosa M. Reguera (Author), Rafael Balaña-Fouce (Author), Birgitta R. Knudsen (Author), Francisco Palacios (Author), Concepcion Alonso (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of aminophenylphosphonates, aldehydes, and styrenes and subsequent oxidation with 2...