NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

• المؤلفون الرئيسيون: Xiaoli Fan (مؤلف), Dandan Yin (مؤلف), Ruoting Men (مؤلف), Heng Xu (مؤلف), Li Yang (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. A total of 149 Chinese AIH patients with a history of AZA treatment were retros...