NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

• Những tác giả chính: Xiaoli Fan (Tác giả), Dandan Yin (Tác giả), Ruoting Men (Tác giả), Heng Xu (Tác giả), Li Yang (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. A total of 149 Chinese AIH patients with a history of AZA treatment were retros...