Computational Optimization of Bioanalytical Parameters for the Evaluation of the Toxicity of the Phytomarker 1,4 Napthoquinone and its Metabolite 1,2,4-trihydroxynapththalene

• Main Authors: Velmani Gopal (Author), Mohammad Harun AL Rashid (Author), Sayani Majumder (Author), Partha Pratim Maiti (Author), Subhash C Mandal (Author)
• Format: Book
• Published: Korean Pharmacopuncture Institute, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Lawsone (1,4 naphthoquinone) is a non redox cycling compound that can be catalyzed by DT diaphorase (DTD) into 1,2,4-trihydroxynaphthalene (THN), which can generate reactive oxygen species by auto oxidation. The purpose of this study was to evaluate the toxicity of the phytomarker 1,4 na...