Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

• Main Authors: Martin Houde (Author), Adel Schwertani (Author), Hanène Touil (Author), Louisane Desbiens (Author), Otman Sarrhini (Author), Roger Lecomte (Author), Martin Lepage (Author), Hugo Gagnon (Author), Shinji Takai (Author), Gunnar Pejler (Author), Danielle Jacques (Author), Fernand Gobeil (Author), Robert Day (Author), Pedro D'Orléans-Juste (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI). Anesthetized 4-month old male wild-type (WT) C57BL/6J m...