The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats

• Main Authors: Ping Ma (Author), Ning Huang (Author), Jun Tang (Author), Zunjie Zhou (Author), Jing Xu (Author), Yi Chen (Author), Maoxin Zhang (Author), Qin Huang (Author), Yuan Cheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cerebral edema (CE) exerts an important effect on brain injury after traumatic brain injury (TBI). Upregulation of transient receptor potential melastatin 4 (TRPM4) in vascular endothelial cells (ECs) results in damage to capillaries and the blood-brain barrier (BBB), which is critical for the devel...