Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction

• Main Authors: Isabelle Adant (Author), Matthew Bird (Author), Bram Decru (Author), Petra Windmolders (Author), Marie Wallays (Author), Peter de Witte (Author), Daisy Rymen (Author), Peter Witters (Author), Pieter Vermeersch (Author), David Cassiman (Author), Bart Ghesquière (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is crucial for the developmen...