Joint modeling of tumor dynamics and progression‐free survival in advanced breast cancer: Leveraging data from amcenestrant early phase I-II trials

• Główni autorzy: Marc Cerou (Autor), Hoai‐Thu Thai (Autor), Laure Deyme (Autor), Sophie Fliscounakis‐Huynh (Autor), Emmanuelle Comets (Autor), Patrick Cohen (Autor), Sylvaine Cartot‐Cotton (Autor), Christine Veyrat‐Follet (Autor)
• Format: Książka
• Wydane: Wiley, 2024-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract A joint modeling framework was developed using data from 75 patients of early amcenestrant phase I-II AMEERA‐1‐2 dose escalation and expansion cohorts. A semi‐mechanistic tumor growth inhibition (TGI) model was developed. It accounts for the dynamics of sensitive and resistant tumor cells,...