Joint modeling of tumor dynamics and progression‐free survival in advanced breast cancer: Leveraging data from amcenestrant early phase I-II trials

• Main Authors: Marc Cerou (Author), Hoai‐Thu Thai (Author), Laure Deyme (Author), Sophie Fliscounakis‐Huynh (Author), Emmanuelle Comets (Author), Patrick Cohen (Author), Sylvaine Cartot‐Cotton (Author), Christine Veyrat‐Follet (Author)
• 格式: 图书
• 出版: Wiley, 2024-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract A joint modeling framework was developed using data from 75 patients of early amcenestrant phase I-II AMEERA‐1‐2 dose escalation and expansion cohorts. A semi‐mechanistic tumor growth inhibition (TGI) model was developed. It accounts for the dynamics of sensitive and resistant tumor cells,...