A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers

• Main Authors: Cécile L. Berends (Author), Lisa Pagan (Author), Michiel J. vanEsdonk (Author), Naomi B. Klarenbeek (Author), Kirsten R. Bergmann (Author), Matthijs Moerland (Author), Vincent van derWel (Author), Saco J. deVisser (Author), Hans Büller (Author), Frans deLoos (Author), Wouter S. deVries (Author), Hans Waals (Author), Leo G. J. deLeede (Author), Jacobus Burggraaf (Author), Ingrid M. C. Kamerling (Author)
• Format: Book
• Published: Wiley, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The strict intake regimen of cysteamine bitartrate formulations, associated with side effects, is a concern for the treatment compliance in cystinosis therapy. Therefore, there is a need for a cysteamine formulation with an improved pharmacokinetic profile. This study investigated the pharm...