Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Objective: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. Methods: We utilize flux balance c...

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Main Authors: Christopher Nogiec (Author), Alison Burkart (Author), Jonathan M. Dreyfuss (Author), Carles Lerin (Author), Simon Kasif (Author), Mary-Elizabeth Patti (Author)
Format: Book
Published: Elsevier, 2015-03-01T00:00:00Z.
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