Cell surface GRP78 regulates TGFβ1-mediated profibrotic responses via TSP1 in diabetic kidney disease

• 主要な著者: Jackie Trink (著者), Usman Ahmed (著者), Kian O'Neil (著者), Renzhong Li (著者), Bo Gao (著者), Joan C. Krepinsky (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Introduction: Diabetic kidney disease (DKD) is the leading cause of kidney failure in North America, characterized by glomerular accumulation of extracellular matrix (ECM) proteins. High glucose (HG) induction of glomerular mesangial cell (MC) profibrotic responses plays a central role in its pathog...