Relationship between factor VIII levels and bleeding for rFVIII‐SingleChain in severe hemophilia A: A repeated time‐to‐event analysis

• Main Authors: Laura H. Bukkems (Author), Siv Jönsson (Author), Marjon H. Cnossen (Author), Mats O. Karlsson (Author), Ron A. A. Mathôt (Author), the OPTI‐CLOT studies and the SYMPHONY consortium (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Publications on the exposure‐effect relationships of factor concentrates for hemophilia treatment are limited, whereas such analyses give insight on treatment efficacy. Our objective was to examine the relationship between the dose, factor VIII (FVIII) levels and bleeding for rFVIII‐SingleC...