Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds

Compounds containg catechol or bisphosphonate were tested as inhibitors of the zinc metalloproteases, thermolysin (TLN), pseudolysin (PLN) and aureolysin (ALN) which are bacterial virulence factors, and the human matrix metalloproteases MMP-9 and −14. Inhibition of virulence is a putative strategy i...

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Main Authors: Fatema Rahman (Author), Tra-Mi Nguyen (Author), Olayiwola A. Adekoya (Author), Cristina Campestre (Author), Paolo Tortorella (Author), Ingebrigt Sylte (Author), Jan-Olof Winberg (Author)
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Publicado em: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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