An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

• मुख्य लेखकों: Alessia Caputo (लेखक), Sara Sartini (लेखक), Elisabetta Levati (लेखक), Ilaria Minato (लेखक), Gian Marco Elisi (लेखक), Adriana Di Stasi (लेखक), Catherine Guillou (लेखक), Peter G. Goekjian (लेखक), Pierre Garcia (लेखक), David Gueyrard (लेखक), Stéphane Bach (लेखक), Arnaud Comte (लेखक), Simone Ottonello (लेखक), Silvia Rivara (लेखक), Barbara Montanini (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein-protein interaction...