An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

• Main Authors: Alessia Caputo (Author), Sara Sartini (Author), Elisabetta Levati (Author), Ilaria Minato (Author), Gian Marco Elisi (Author), Adriana Di Stasi (Author), Catherine Guillou (Author), Peter G. Goekjian (Author), Pierre Garcia (Author), David Gueyrard (Author), Stéphane Bach (Author), Arnaud Comte (Author), Simone Ottonello (Author), Silvia Rivara (Author), Barbara Montanini (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein-protein interaction...