Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

• Main Authors: Yi Qian (Author), Meimei Zhao (Author), Qinghua Han (Author), Jingkang Wang (Author), Lixi Liao (Author), Heng Yang (Author), Dan Liu (Author), Pengfei Tu (Author), Hong Liang (Author), Kewu Zeng (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin cytoskeleton proteins. Thus, targeting myosin-actin molec...