Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

• Autori principali: Johanna K. Freundt (Autore), Gerrit Frommeyer (Autore), Tilmann Spieker (Autore), Fabian Wötzel (Autore), Jochen Schulze Grotthoff (Autore), Jörg Stypmann (Autore), Georg Hempel (Autore), Michael Schäfers (Autore), Andreas H. Jacobs (Autore), Lars Eckardt (Autore), Philipp S. Lange (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2019-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here...