Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation

• Main Authors: Soo-Jin Lee (Author), Ji-Woong Shin (Author), Mee-Ae Kwon (Author), Ki Baek Lee (Author), Hyo-Jun Kim (Author), Jin-Haeng Lee (Author), Heun-Soo Kang (Author), Jong Kwan Jun (Author), Sung-Yup Cho (Author), In-Gyu Kim (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transglutaminase 2 (TG2) is a multifunctional enzyme that exhibits transamidase, GTPase, kinase, and protein disulfide isomerase (PDI) activities. Of these, transamidase-mediated modification of proteins regulates apoptosis, differentiation, inflammation, and fibrosis. TG2 is highly expressed in mes...