TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3

• Main Authors: Raquel Espín (Author), Francisco J. Roca (Author), Sergio Candel (Author), María P. Sepulcre (Author), Juan M. González-Rosa (Author), Francisca Alcaraz-Pérez (Author), José Meseguer (Author), María L. Cayuela (Author), Nadia Mercader (Author), Victoriano Mulero (Author)
• Format: Book
• Published: The Company of Biologists, 2013-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here, we show that targeted gene knockdown...