Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant

• Huvudskapare: Mariam R. Habil (Författare, medförfattare), Mark A. Doll (Författare, medförfattare), David W. Hein (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme that uses acetyl coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic amines and alkylanilines. NAT1 is characterized by single nucleotide polymorphisms (SNPs) that may modulate affinity towards AcC...