8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

• 主要な著者: Damijan Knez (著者), Daniel Diez-Iriepa (著者), Mourad Chioua (著者), Andrea Gottinger (著者), Milica Denic (著者), Fabien Chantegreil (著者), Florian Nachon (著者), Xavier Brazzolotto (著者), Anna Skrzypczak-Wiercioch (著者), Anže Meden (著者), Anja Pišlar (著者), Janko Kos (著者), Simon Žakelj (著者), Jure Stojan (著者), Kinga Sałat (著者), Julia Serrano (著者), Ana Patricia Fernández (著者), Aitana Sánchez-García (著者), Ricardo Martínez-Murillo (著者), Claudia Binda (著者), Francisco López-Muñoz (著者), Stanislav Gobec (著者), José Marco-Contelles (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weigh...