8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

• Main Authors: Damijan Knez (Author), Daniel Diez-Iriepa (Author), Mourad Chioua (Author), Andrea Gottinger (Author), Milica Denic (Author), Fabien Chantegreil (Author), Florian Nachon (Author), Xavier Brazzolotto (Author), Anna Skrzypczak-Wiercioch (Author), Anže Meden (Author), Anja Pišlar (Author), Janko Kos (Author), Simon Žakelj (Author), Jure Stojan (Author), Kinga Sałat (Author), Julia Serrano (Author), Ana Patricia Fernández (Author), Aitana Sánchez-García (Author), Ricardo Martínez-Murillo (Author), Claudia Binda (Author), Francisco López-Muñoz (Author), Stanislav Gobec (Author), José Marco-Contelles (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weigh...