Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics

• Main Authors: Aliede E. in 't Veld (Author), Manon A. A. Jansen (Author), Bertine W. Huisman (Author), Mascha Schoonakker (Author), Marieke L. de Kam (Author), Dirk Jan A. R. Moes (Author), Mariëtte I. E. van Poelgeest (Author), Jacobus Burggraaf (Author), Matthijs Moerland (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic drug monitoring (TDM) of calcineurin inhibitors (i.e., tacrolimus and cyclosporin A) is standard of care after solid organ transplantation. Although the incidence of acute rejection has strongly decreased, there are still many patients who experience severe side effects or rejection afte...