DPP-4 inhibition protects human umbilical vein endothelial cells from hypoxia-induced vascular barrier impairment

• Main Authors: Naoko Hashimoto (Author), Kento Ikuma (Author), Yui Konno (Author), Masanori Hirose (Author), Hiroyuki Tadokoro (Author), Hiroshi Hasegawa (Author), Yoshio Kobayashi (Author), Hiroyuki Takano (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dipeptidyl peptidase-4 (DPP-4) inhibitors are relatively new class of anti-diabetic drugs. Some protective effects of DPP-4 on cardiovascular disease have been described independently from glucose-lowering effect. However, the detailed mechanisms by which DPP-4 inhibitors exert on endothelial cells...