Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction

• Main Authors: Veronica Marcos (Author), Zhe Zhou-Suckow (Author), Ali Önder Yildirim (Author), Alexander Bohla (Author), Andreas Hector (Author), Ljubomir Vitkov (Author), Wolf Dietrich Krautgartner (Author), Walter Stoiber (Author), Matthias Griese (Author), Oliver Eickelberg (Author), Marcus A. Mall (Author), Dominik Hartl (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF). CF airways are characterized by a nonresolving neutrophilic inflammation. After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, f...