Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design

• Main Authors: Yoon Tae Goo (Author), Sangkil Lee (Author), Ji Yeh Choi (Author), Min Song Kim (Author), Gi Hyeong Sin (Author), Sun Ho Hong (Author), Chang Hyun Kim (Author), Seh Hyon Song (Author), Young Wook Choi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lipophilicity of a peptide drug can be considerably increased by hydrophobic ion pairing with amphiphilic counterions for successful incorporation into lipid-based formulations. Herein, to enhance the oral absorption of insulin (INS), a self-microemulsifying drug delivery system (SMEDDS) formula...