Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

• Główni autorzy: Joshua M. Corbin (Autor), Constantin Georgescu (Autor), Jonathan D. Wren (Autor), Chao Xu (Autor), Adam S. Asch (Autor), Maria J. Ruiz-Echevarría (Autor)
• Format: Książka
• Wydane: Elsevier, 2021-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...