Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

• Main Authors: Joshua M. Corbin (Author), Constantin Georgescu (Author), Jonathan D. Wren (Author), Chao Xu (Author), Adam S. Asch (Author), Maria J. Ruiz-Echevarría (Author)
• 格式: 图书
• 出版: Elsevier, 2021-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...