Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

• Main Authors: Azizah M. Malebari (Author), Shu Wang (Author), Thomas F. Greene (Author), Niamh M. O'Boyle (Author), Darren Fayne (Author), Mohemmed Faraz Khan (Author), Seema M. Nathwani (Author), Brendan Twamley (Author), Thomas McCabe (Author), Daniela M. Zisterer (Author), Mary J. Meegan (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel 3-chloro-β-lactams and 3,3-dichloro-β-lactams (2-...