Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

• Main Authors: Gabriel Silva Marques Borges (Author), Pedro Henrique Dias Moura Prazeres (Author), Ângelo Malachias de Souza (Author), Maria Irene Yoshida (Author), José Mario Carneiro Vilela (Author), Aline Teixeira Maciel e Silva (Author), Mariana Silva Oliveira (Author), Dawidson Assis Gomes (Author), Margareth Spangler Andrade (Author), Elaine Maria de Souza-Fagundes (Author), Lucas Antônio Miranda Ferreira (Author)
• Format: Book
• Published: Universidade de São Paulo, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN...