Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

• मुख्य लेखकों: Zhijun Wang (लेखक), Bogdan Z. Olenyuk (लेखक), Jean Chen Shih (लेखक), Jeffrey Wang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A high-performance liquid chromatography-electrospray ionization tandem mass spectrometric (HPLC-ESI-MS/MS) method was developed for the quantification of MHI148-clorgyline amide (NMI-amide), a novel tumor-targeting monoamine oxidase A inhibitor, in mouse plasma. The method was validated in terms of...