Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug

• Main Authors: Mengbi Yang (Author), Amy Q. Wang (Author), Elias C. Padilha (Author), Pranav Shah (Author), Natalie R. Hagen (Author), China Ryu (Author), Khalida Shamim (Author), Wenwei Huang (Author), Xin Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Niclosamide (Nc) is an FDA-approved anthelmintic drug that was recently identified in a drug repurposing screening to possess antiviral activity against SARS-CoV-2. However, due to the low solubility and permeability of Nc, its in vivo efficacy was limited by its poor oral absorption.M...