Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development?

• Main Authors: Supratik Das (Author), Rajesh Kumar (Author), Shubbir Ahmed (Author), Hilal Ahmad Parray (Author), Sweety Samal (Author)
• Format: Book
• Published: SAGE Publishing, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The enormous diversity of HIV-1 is a significant impediment in selecting envelopes (Envs) that can be suitable for designing vaccine immunogens. While tremendous progress has been made in developing soluble, trimeric, native-like Env proteins, those that have elicited neutralizing antibodies (Abs) i...