Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue

• Main Authors: Carly T. Cederquist (Author), Claudia Lentucci (Author), Camila Martinez-Calejman (Author), Vanessa Hayashi (Author), Joseph Orofino (Author), David Guertin (Author), Susan K. Fried (Author), Mi-Jeong Lee (Author), M. Dafne Cardamone (Author), Valentina Perissi (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin signaling plays a unique role in the regulation of energy homeostasis and the impairment of insulin action is associated with altered lipid metabolism, obesity, and Type 2 Diabetes. The main aim of this study was to provide further insight into the regulatory mechanisms governing...